报告地点： 教场东路园区 主楼322会议室 

　报告一 

　报告人：Xin Li Assistant Professor (New York University) 

　题目：A new function of an old metabolite: succinate connects hyperglycemia and periodontitis　

Dr. Li is a tenured Associate Professor in Department of Basic Science and Craniofacial Biology at New York University. She holds appointment at both College of Dentistry and Langone Medical School. Dr. Li research is focused on the impact of metabolites that function as non-autonomous signals in pathophysiological conditions such as aging and diabetes. 

　　Recently, their group found that succinate, a TCA cycle metabolite was significantly elevated in mammalian and bacteria exposed to high glucose. Dr. Li recent paper in Nature Communications demonstrates that succinate enhances osteoclastogenesis through its receptor Sucnr1 in vitro and in vivo. Their finding revealed a novel mechanism of succinate and its G-protein coupled receptor (SUCNR1) in osteoclastogenesis, inflammaging, periodontitis, and aging-related bone loss. 

　报告二

　报告人：吴英杰 教授 

　题目：IGF1 level and Nonalcoholic Fatty Liver Disease in growth hormone receptor knockout mice　

博士，教授，博士生导师，大连医科大学重大疾病基因工程模式动物研究所所长，科技部基因工程模式动物国际联合研究中心主任。美国西奈山医学院内分泌糖尿病及骨疾病系兼职副教授。辽宁省攀登学者获得者，教育部创新团队骨干成员。国家重大人才工程“创新人才推进计划”领军人才和创新团队评议专家，国家国际科技合作战略专家，项目评审专家。主持国家自然科学基金项目及科技部国际合作项目等10余项。 

　　吴英杰教授长期致力于基因工程技术方面的研究。利用改进的高通量Cre-LoxP系统和CRISPR/Cas9介导的基因重组技术建立多个组织特异性基因敲除小鼠动物模型；以研究GH-IGF1轴信号通路中基因在不同时间、组织或细胞中在正常及病理条件下的功能，为研究糖尿病、肥胖、骨疾病、肿瘤和老年病分子机制及治疗奠定理论基础。在国际著名期刊，如Science、Cell、The Journal of Clinical Investigation、Nature Communication、Diabetes、Endocrinology、Cancer Research和Journal of Bone and Mineral Research发表相关论文60余篇，被引用次数总计达3000余次。 

　　欢迎全所师生参加报告会及会后交流！ 

　　动物模型与人类疾病机理重点实验室 

　　脂类代谢与疾病学科组 

　　2018年9月17日