报告题目:Autophagy and Nrf2 in Liver Injury and Tumorigenesis: Two Sides of the Same Coin?
报告人:丁文兴 教授,美国堪萨斯大学医学中心
报告时间: 2018年6月22日(星期五)16:00
报告地点: 教场东路园区 主楼327会议室
丁文兴教授现任美国堪萨斯大学医学中心药理毒理学和治疗学系终身教授。丁老师长期以来致力于酒精和药物性肝损伤以及肝肿瘤中细胞死亡和自噬分子机制的研究,目前主要关注自噬在药源性肝损伤、酒精及非酒精性脂肪肝等肝脏疾病中的作用及分子机制。相关研究成果已在Gastroenterology, Hepatology, J Hepatology, Autophagy, Mol Cancer Ther, Am J Pathol, J Biol Chem等国际著名学术期刊上发表100多篇学术论文。目前担任Autophagy副主编,Am J Pathol,Hepatology等杂志编委,同时兼任美国病理学研究学会、美国肝病研究学会委员等。
欢迎全所师生参加报告会及会后交流!
动物模型与人类疾病机理重点实验室
脂类代谢与疾病学科组
2018年6月15日
近期论文
1. Chao, X., Wang, S.G., Zhao, K., Li, Y., Li, T., He, C., Li, L., Ballabio, A., Ni, H.M. and Ding, W.X. (2018) Impaired TFEB-mediated lysosomal biogenesis in acute-on-chronic alcohol induced-liver injury in mice. Gastroenterology. PMID: 29782848.
2. Wang, S and Ding, W.X (2018) Does Autophagy Promote or Protect Against the Pathogenesis of Pancreatitis? Gastroenterology (accepted).
3. Chao, X., Ni, H.M. and Ding, W.X. (2018) Insufficient Autophagy: A Novel Autophagic Flux Scenario Uncovered by Impaired Liver TFEB-Mediated Lysosomal Biogenesis From Chronic Alcohol-Drinking Mice. Autophagy (accepted).
4. Wang Y, Ding WX and Li T. (20108) Cholestrol and bile acid-mediated regulation of autophagy in fatty liver diseases and atherosclerosis. Biochim Biophys Acta. 2018 Apr 10;1863(7):726-733. PMID: 29653253.
5. Qiang, H, Wang, S and Ding, W.X. (2018) A PINK1-Mediated Mitophagy Pathway Decides the Fate a Tumor to be Benign or Malignant? Autophagy.9: 1-13. PMID 29313453.PMCID:
6. Wang, S., Wang, H, and Ding, W.X. (2018) Pyroptosis, a novel target for alcoholic hepatitis? Hepatology. ;67(5):1660-1662. PMID: 29222919. PMCID: PMC5906175.