报告题目：Regulation of metabolism and neurocognition by the circadian clock and histone deacetylase 3 

　　报告人：Zheng Sun Assistant Professor (Baylor College of Medicine) 

　　报告时间： 2018年6月15日（星期五）16:00 

　　报告地点： 教场东路园区 主楼237会议室 

　　Zheng Sun is focused on nuclear hormone receptors and its coregulators in metabolism and aging-associated diseases. His team is particularly interested in epigenomic regulatory mechanism and the role of circadian rhythm in glucose, lipid, and amino acid metabolism. 

　　欢迎全所师生参加报告会及会后交流！ 

　　动物模型与人类疾病机理重点实验室 

　　脂类代谢与疾病学科组 

　　2018年6月15日 

　　代表论文 

　　1. Hong S, Zhou W, Fang B, Lu W, Loro E, Damle M, Ding G, Jager J, Zhang S, Zhang Y, Feng D, Chu Q, Dill BD, Molina H, Khurana TS, Rabinowitz JD, Lazar MA, Sun Z. (2017) Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3. Nat Med. 23(2):223-234. 

　　2. Gong Y, Cao R, Ding G, Hong S, Zhou W, Lu W, Damle M, Fang B, Wang CC, Qian J, Lie N, Lanzillotta C, Rabinowitz JD, Sun Z. (2017) Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle. Mol Cell Endocrinol. S0303-7207(17)30293-9. 

　　3. Papazyan R, Sun Z, Kim YH, Titchenell PM, Hill DA, Lu W, Damle M, Wan M, Zhang Y, Briggs ER, Rabinowitz JD, Lazar MA. (2016) Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. Cell Metab. 24(6):863-874. 

　　4. Zhang Y, Fang B, Emmett MJ, Damle M, Sun Z, Feng D, Armour SM, Remsberg JR, Jager J, Soccio RE, Steger DJ, Lazar MA. (2015) Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock. Science. 348(6242):1488-92. 

　　5. Fang B, Everett LJ, Jager J, Briggs E, Armour SM, Feng D, Roy A, Gerhart-Hines Z, Sun Z, Lazar MA. (2014) Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo. Cell. 159(5): 1140-52. 

　　6. You SH, Lim HW, Sun Z, Broache M, Won KJ, Lazar MA. (2013) Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo. Nat Struct Mol Biol. 20(2):182-7. 

　　7. Sun Z, Lazar MA. (2013) Dissociating fatty liver and diabetes. Trends Endocrinol Metab. 24(1):4-12. 

　　8. Sun Z, Feng D, Fang B, Mullican SE, You SH, Lim HW, Everett LJ, Nabel CS, Li Y, Selvakumaran V, Won KJ, Lazar MA. (2013) Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor. Mol Cell. 52(6):769-82.