时间:2018年1月17日(星期三)上午9:30-12:00
地点:教场东路园区主楼327会议室
报告1:基因工程模式动物疾病模型——从基础医学到临床研究的桥梁
报告人:吴英杰教授
报告2:Drug Discovery Learnings:The discovery story of Singulair (顺尔宁), and the Liver targeted SCD1 Inhibitor.
报告人: Zheng Huang教授
专家简介:
吴英杰教授:博士生导师,大连医科大学重大疾病基因工程模式动物研究所所长,科技部基因工程模式动物国际联合研究中心主任,美国西奈山医学院内分泌糖尿病及骨疾病系兼职副教授。辽宁省攀登学者获得者,教育部创新团队骨干成员。国家重大人才工程“创新人才推进计划”领军人才和创新团队评议专家,国家国际科技合作战略专家,项目评审专家。主持国家自然科学基金项目及科技部国际合作项目等10余项。吴英杰教授长期致力于基因工程技术方面的研究,利用改进的高通量Cre-LoxP系统和CRISPR/Cas9介导的基因重组技术建立多个组织特异性基因敲除小鼠动物模型;以研究GH-IGF1轴信号通路中基因在不同时间、组织或细胞中在正常及病理条件下的功能,为研究糖尿病、肥胖、骨疾病、肿瘤和老年病分子机制及治疗奠定理论基础。在国际著名期刊,如Science、Cell、The Journal of Clinical Investigation、Nature Communication、 Diabetes、Endocrinology、Cancer Research和Journal of Bone and Mineral Research发表相关论文60余篇,被引用次数总计达3000余次。
Zheng Huang教授:
1990-1991: Research Associate, Canadian Protein Centre of xcellence, University of Toronto.
1991-2009: Senior Research Fellow, Merck Frosst (started as a Senior Research Biologist).
2010-2011: CSO of Future Pharmaceutical Research Company of Canada Ltd.
2011-Present: Biology Director, Eli Lilly China Diabetes Research and Development Center.
25 years of drug hunting and project management experience with track records, his teams discovered multiple molecules into advanced clinic development, including liver-targeted SCD inhibitors for diabetes & dyslipidemia, PDE4 inhibitors for COPD, rheumatoid arthritis, psoriasis and cognition improvement, dual nitric oxide-releasing/cyclo-oxygenase inhibitor for pain relief, also his team discovered SCD inhibition suppresses HCV infection. He was uaually invited to give Lectures in the international famous academic meeting and his research results were published in the related fields of the international famous journals.
欢迎感兴趣的老师和同学届时参加!
脂类代谢与疾病学科组
动物模型与人类疾病机理重点实验室
2018年1月17日